Synthesis of Glycoconjugates
نویسندگان
چکیده
منابع مشابه
Synthesis of protoescigenin glycoconjugates with O-28 triazole linker.
New triazole linked conjugates were obtained from protoescigenin monopropargyl ethers and sugar azides, under Cu(II) salt promotion in good yield, without losing isopropylidene protection.
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Multivalency effects are essential in carbohydrate recognition processes as occurring on the cell surface. Thus many synthetic multivalent glycoconjugates have been developed as important tools for glycobiological research. We are expanding this collection of molecules by the introduction of carbohydrate-scaffolded divalent glycothymine derivatives that can be intramolecularily dimerized by [2 ...
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In conclusion, either enzymatic or chemical approaches have their unique features and unavoidable disadvantages. Enzyme-catalyzed sialylations provide the desired sialo-glycosidic linkages in the two enzyme reactions (CMP-NeuAc synthetase and sialyltransferase) with exclusive stereoselectivity and high yield as long as the required sialyltransferase is available. High substrate specificity of t...
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ژورنال
عنوان ژورنال: Kobunshi
سال: 1996
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.45.539